Detail of GB 31604.57-2023

Introduction of GB 31604.57-2023

GB 31604.57-2023 National food safety standard - Determination of migration of benzophenone substances in food contact materials and articles 1 Scope This standard specifies the determination method of migration quantity of eight kinds of benzophenone substances in food contact materials and articles. Method I - Liquid chromatography is applicable to determination of the migration quantities of (2-hydroxy-4-methoxyphenyl) (2-hydroxyphenyl) ketone, 2, 4-dihydroxybenzophenone, (2-hydroxy-4-methoxyphenyl) phenylketone, 4, 4'-dihydroxybenzophenone, 2-hydroxy-4-n-octyloxybenzophenone, 2-hydroxy-4-n-hexyloxybenzophenone, benzophenone and 4, 4'-difluorobenzophenone from plastics, paint and coating, rubber, and food contact materials and articles using ink in food simulants of water, 4% (v/v) acetic acid, 10% (v/v) ethanol, 20% (v/v) ethanol and 50% (v/v) ethanol, and chemical alternative solvents 95% (v/v) ethanol and isooctane. Method II - Liquid chromatography - Tandem mass spectrometry is applicable to determination of the migration quantities of (2-hydroxy-4-methoxyphenyl) (2-hydroxyphenyl) ketone, 2, 4-dihydroxybenzophenone, (2-hydroxy-4-methoxyphenyl) phenylketone, 4, 4'-dihydroxybenzophenone, 2-hydroxy-4-n-octyloxybenzophenone, 2-hydroxy-4-n-hexyloxybenzophenone, benzophenone and 4, 4'-difluorobenzophenone from plastics, paint and coating, rubber, and food contact materials and articles using ink in food simulants of water, 4% (v/v) acetic acid, 10% (v/v) ethanol, 20% (v/v) ethanol and 50% (v/v) ethanol and olive oil, and chemical alternative solvents 95% (v/v) ethanol and isooctane. Method I Liquid chromatography 2 Principle Food contact materials and articles are subjected to migration test according to GB 31604.1 and GB 5009.156, and then detected by liquid chromatography. The food simulants of water, 4% (v/v) acetic acid, 10% (v/v) ethanol, 20% (v/v) ethanol, and 50% (v/v) ethanol can be directly injected. The chemical alternative solvent of 95% (v/v) ethanol is diluted with water, filtered, and then injected. The chemical alternative solvent of isooctane is blown with nitrogen, redissolved in an aqueous methanol solution, filtered, and then injected. Quantification is carried out by the external standard method using peak area. 3 Reagents and materials Unless otherwise stated, reagents used in this method are analytically pure, and the water is Grade I water as specified in GB/T 6682. 3.1 Reagents 3.1.1 Glacial acetic acid (CH3COOH). 3.1.2 Absolute ethanol (C2H5OH). 3.1.3 Isooctane (C8H18). 3.1.4 Methanol (CH3OH): chromatographically pure. 3.1.5 Dimethyl sulfoxide (C2H6OS). 3.2 Preparation of reagents 3.2.1 4% (v/v) acetic acid solution, 10% (v/v) ethanol solution, 20% (v/v) ethanol solution and 50% (v/v) ethanol solution are prepared according to GB 5009.156. 3.2.2 95% (v/v) ethanol solution: Mix absolute ethanol and water at a volume ratio of 95:5. 3.2.3 Aqueous methanol solution (7+3): Mix methanol and water at a volume ratio of 7:3. 3.3 Standards 3.3.1 (2-hydroxy-4-methoxyphenyl) (2-hydroxyphenyl) ketone (C14H12O4, CAS No.: 131-53-3): A standard substance with a purity greater than or equal to 98%, or certified by the state and granted with a certificate for standards. 3.3.2 2, 4-dihydroxybenzophenone (C13H10O3, CAS No.: 131-56-6): A standard substance with a purity greater than or equal to 98%, or certified by the state and granted with a certificate for standards. 3.3.3 (2-hydroxy-4-methoxyphenyl) phenylketone (C14H12O3, CAS No.: 131-57-7): A standard substance with a purity greater than or equal to 98%, or certified by the state and granted with a certificate for standards. 3.3.4 4, 4'-dihydroxybenzophenone (C13H10O3, CAS No.: 611-99-4): A standard substance with a purity greater than or equal to 98%, or certified by the state and granted with a certificate for standards.

Contents of GB 31604.57-2023

Foreword i 1 Scope Method I Liquid chromatography 2 Principle 3 Reagents and materials 4 Apparatus 5 Analytical procedures 6 Expression of analysis results 7 Accuracy 8 Others Method II Liquid chromatography-Tandem mass spectrometry 9 Principle 10 Reagents and materials 11 Apparatus 12 Analytical procedures 13 Expression of analysis results 14 Accuracy 15 Others Annex A Liquid chromatograms for standard solutions of 8 kinds of benzophenones Annex B Mass spectrometry reference conditions Annex C Total ion current (TIC) chromatograms of 8 benzophenones by liquid chromatography-tandem mass spectrometry