GB/T 23876-2009 Feed additive - L-carnitine hydrochloride
1 Scope
This standard specifies the requirements, test methods, inspection rules, marking, packaging, transportation and storage of feed additive L-carnitine hydrochloride.
This standard is applicable to L-carnitine hydrochloride prepared from epichlorohydrin as the starting material.
Molecular formula: C7H16ClNO3
Relative molecular mass: 197.66 (as per the international relative atomic mass in 2007)
Structural formula:
2 Normative references
The following documents contain provisions which, through reference in this text, constitute provisions of this standard. For dated references, subsequent amendments (excluding corrections) to, or revisions, of any of these publications do not apply. However, parties to agreements based on this standard are encouraged to investigate the possibility of applying the most recent editions of the normative documents indicated below. For undated references, the latest edition applies.
GB/T 601 Chemical reagent - Preparations of reference titration solutions
GB/T 602 Chemical reagent - Preparations of standard solutions for impurity
GB/T 603 Chemical reagent - Preparations of reagent solutions for use in test methods
GB/T 6439 Determination of water - soluble chlorides in feeds
GB/T 6682 Water for analytical laboratory use - Specification and test methods
GB 10648 Feed label
GB/T 13079 Determination of total arsenic in feeds
GB/T 13084 Determination of cyanide in feed
GB/T 14699.1 Feeding stuffs - Sampling
Pharmacopoeia of the People’s Republic of China (Volume II) (2005 Edition)
3 Requirements
3.1 Properties
The product is white or white-like crystalline powder with slightly fishy taste and hygroscopicity, which is very soluble in water, soluble in anhydrous methanol and anhydrous ethanol, slightly soluble in acetone, insoluble in trichloromethane, and easy to agglomerate after long-term storage.
3.2 Technical indicators
The technical indicators shall meet those specified in Table 1.
Table 1 Main technical indicators of L-carnitine hydrochloride
Item Indicator
Content (by dry matter)/% 98.0~102.0
Specific rotation (by dry matter)/(°) -21.3~-23.5
pH (1% aqueous solution) 2.5~2.9
Loss on drying/% ≤0.5
Chloride (by Cl-)/% 17.0~18.5
Heavy metals (by Pb)/(mg/kg) ≤10
Arsenic salt (by As)/(mg/kg) ≤2
Cyanide Not detectable
Ignition residue/% ≤0.3
4 Test methods
Unless otherwise specified, only recognized analytically pure reagents and Class-III water specified in GB/T 6682 are used for the analysis; the standard solution and impurity solution shall be prepared in accordance with GB/T 601, GB/T 602 and GB/T 603.
4.1 Reagents and materials
4.1.1 Glacial acetic acid.
4.1.2 Glycerin.
4.1.3 Methanol: chromatographically pure.
4.1.4 Potassium dihydrogen phosphate.
GB/T 23876-2009 Feed additive - L-carnitine hydrochloride
1 Scope
This standard specifies the requirements, test methods, inspection rules, marking, packaging, transportation and storage of feed additive L-carnitine hydrochloride.
This standard is applicable to L-carnitine hydrochloride prepared from epichlorohydrin as the starting material.
Molecular formula: C7H16ClNO3
Relative molecular mass: 197.66 (as per the international relative atomic mass in 2007)
Structural formula:
2 Normative references
The following documents contain provisions which, through reference in this text, constitute provisions of this standard. For dated references, subsequent amendments (excluding corrections) to, or revisions, of any of these publications do not apply. However, parties to agreements based on this standard are encouraged to investigate the possibility of applying the most recent editions of the normative documents indicated below. For undated references, the latest edition applies.
GB/T 601 Chemical reagent - Preparations of reference titration solutions
GB/T 602 Chemical reagent - Preparations of standard solutions for impurity
GB/T 603 Chemical reagent - Preparations of reagent solutions for use in test methods
GB/T 6439 Determination of water - soluble chlorides in feeds
GB/T 6682 Water for analytical laboratory use - Specification and test methods
GB 10648 Feed label
GB/T 13079 Determination of total arsenic in feeds
GB/T 13084 Determination of cyanide in feed
GB/T 14699.1 Feeding stuffs - Sampling
Pharmacopoeia of the People’s Republic of China (Volume II) (2005 Edition)
3 Requirements
3.1 Properties
The product is white or white-like crystalline powder with slightly fishy taste and hygroscopicity, which is very soluble in water, soluble in anhydrous methanol and anhydrous ethanol, slightly soluble in acetone, insoluble in trichloromethane, and easy to agglomerate after long-term storage.
3.2 Technical indicators
The technical indicators shall meet those specified in Table 1.
Table 1 Main technical indicators of L-carnitine hydrochloride
Item Indicator
Content (by dry matter)/% 98.0~102.0
Specific rotation (by dry matter)/(°) -21.3~-23.5
pH (1% aqueous solution) 2.5~2.9
Loss on drying/% ≤0.5
Chloride (by Cl-)/% 17.0~18.5
Heavy metals (by Pb)/(mg/kg) ≤10
Arsenic salt (by As)/(mg/kg) ≤2
Cyanide Not detectable
Ignition residue/% ≤0.3
4 Test methods
Unless otherwise specified, only recognized analytically pure reagents and Class-III water specified in GB/T 6682 are used for the analysis; the standard solution and impurity solution shall be prepared in accordance with GB/T 601, GB/T 602 and GB/T 603.
4.1 Reagents and materials
4.1.1 Glacial acetic acid.
4.1.2 Glycerin.
4.1.3 Methanol: chromatographically pure.
4.1.4 Potassium dihydrogen phosphate.
