Standard No.:	QB/T 4576-2023
English Name:	Sodium hyaluronate
Chinese Name:	透明质酸钠
Chinese Classification:	X69    Other fermented goods
Professional Classification:	QB    Professional Standard - Light Industry
Source Content Issued by:	MIIT
Issued on:	2023-12-29
Implemented on:	2024-7-1
Status:	valid
Superseding:	QB/T 4576-2013 Sodium hyaluronate
Target Language:	English
File Format:	PDF
Word Count:	7500 words
Translation Price(USD):	225.0
Delivery:	via email in 1 business day

QB/T 4576-2023 Sodium hyaluronate 1 Scope This document specifies the requirements for identification, sensory properties, physicochemical properties and safety of sodium hyaluronate, describes the corresponding test methods, specifies the inspection rules, marking, packaging, transportation and storage, and provides information on the molecular formula, relative molecular mass and structural formula. This document is applicable to the production, inspection and sale of sodium hyaluronate produced by fermentation of Streptococcus equi subsp. zooepidemicus using glucose, yeast extract, peptone, etc. as raw materials. 2 Normative references The following normative documents contain provisions which, through reference in this text, constitute provisions of this document. For dated references, only the edition cited applies. For undated references, the latest edition of the referenced document (including any amendments) applies. GB/T 191 Packaging - Pictorial marking for handling of goods GB/T 601 Chemical reagent - Preparations of reference titration solutions GB/T 602 Chemical reagent - Preparations of standard solutions for impurity GB/T 603-2023 Chemical reagent - Preparations of reagent solutions for use in test methods GB 4789.2 National food safety standard - Food microbiological examination - Aerobic plate count GB 4789.3 National food safety standard - Food microbiological examination - Enumeration of coliforms GB 4789.15 National food safety standard - Food microbiological examination - Enumeration of moulds and yeasts GB 5009.3 National food safety standard - Determination of moisture in foods GB 5009.4 National food safety standard - Determination of ash in foods GB 5009.11 National food safety standard - Determination of total arsenic and abio-arsenic in foods GB 5009.12 National food safety standard - Determination of lead in foods GB/T 6682 Water for analytical laboratory use - Specification and test methods GB 7718 National food safety standard - General standard for the labeling of prepackaged foods 3 Terms and definitions For the purposes of this document, the following terms and definitions apply. 3.1 sodium hyaluronate sodium salt of hyaluronic acid, a chain-like high-molecular acidic mucopolysaccharide composed of disaccharide structural units formed by β-D-N-acetylglucosamine and β-D-glucuronic acid linked via β-1,3-glycosidic bonds, which are further linked via β-1,4-glycosidic bonds Note: Commercial sodium hyaluronate is also referred to as "hyaluronic acid", etc. 4 Molecular formula, relative molecular mass and structural formula 4.1 Molecular formula (C₁₄H₂₀NNaO₁₁)ₙ.

Contents Foreword i 1 Scope 2 Normative references 3 Terms and definitions 4 Molecular formula, relative molecular mass and structural formula 5 Requirements 6 Test methods 7 Inspection rules 8 Marking, packaging, transportation and storage Annex A (Normative) Sodium hyaluronate content——Spectrophotometric method Annex B (Normative) Sodium hyaluronate content——High performance liquid chromatography method Annex C (Informative) High performance liquid chromatograms of sodium hyaluronate